How to take your probiotics

How to take your probiotics

The Bioxyne Team

Dominik Martin

It’s simple. The PCC® in Bioxyne’s products is freeze dried – which means that all you need to do to bring it back to life is to swallow it with plenty of water. 

For proTract for infants with atopic dermatitis, just open a capsule and sprinkle it onto your infant’s drink (if it’s a warm drink, add the probiotic after you have warmed it up).

For adults, you can take one Progastrim® or Progastrim®+Vitamin C capsule with a glass of water every day.

If you are taking antibiotics, wait at least two hours after your antibiotic dose before consuming PCC® in either Progastrim® or proTract products.

This was part four of a four-part series about what probiotics are and why they’re good for you.

Part one: What are probiotics?

Part two: How probiotics are named

Part three: How probiotics work and why they’re good for you



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How probiotics work and why they’re good for us

How probiotics work and why they’re good for us

The Bioxyne Team

Christopher Campbell

Scientists now understand that the health of our gastrointestinal (GI) tract is vital to our health generally. Scientific studies have demonstrated that probiotics can directly influence our health primarily through their effects on the GI tract. These effects include:

  • helping to maintain a healthy balance of intestinal microbes,
  • preventing pathogenic microbes from inhabiting the intestinal tract,
  • boosting the general immune response through stimulating important immune areas located in the intestinal tract,
  • maintaining the health of the intestinal wall to stop bacteria getting through it and causing disease,
  • inhibiting cancer-associated enzymatic activity, and
  • nurturing the intestine’s ability to absorb healthy nutrients.

The health benefits of probiotics

Foods fermented by probiotic bacteria (think kimchee, yoghurt, sauerkraut) have for centuries been revered as health-giving, but it’s only in the last few decades that scientists have begun to compile solid scientific data that supports the association between probiotics and good health.

Have a look at the graph below to see the growth in scientific research on probiotics in the past 20 years.

(Source: NCBI PubMed)

While the association between gastrointestinal health and probiotics has been widely accepted, more recently we’re seeing a clear association between probiotics and immune health.

It’s important to note that unless a probiotic strain has been tested, we don’t really know if it has any health benefits.

Bioxyne’s probiotic PCC® has been scientifically and clinically tested in Australia. Through double-blind, placebo-controlled studies, PCC® has demonstrated clinical efficacy in:

  • reducing the incidence and severity of respiratory infections (colds) in infants and adults
  • reducing the symptoms of moderate to severe atopic dermatitis (eczema) in infants
  • boosting the effectiveness of the FluVax (flu vaccinations)
  • improving bowel function in adults.

This was part three of a four-part series about what probiotics are and why they’re good for you. Next up is ‘How to take your probiotics’.

Part one: What are probiotics

Part two: How probiotics are named


Name: Lactobacillus fermentum VRI-003

Nickname: PCC®

Origin: A human with robust gastrointestinal health

Career Objective: To boost gut and immune health of adults and infants through daily dosing of clinically trialled doses of PCC®.


University of New South Wales:

  • Certificate of High Survival in Stomach Acid and Bile
  • Certificate of Inhibition of Gastrointestinal Pathogens
  • Certificate of Binding to the Intestinal tract

Previous Experience in Humans:

2005: Clinical trial of PCC® showing improvement in symptoms of moderate to severe atopic dermatitis in infants

2008: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

2009: Clinical trial of PCC® showing boost in the immune response to the flu vaccine

2011: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

All of these trials confirmed that PCC® is safe for children and adults

Current Experience in Humans:

2016- present: Clinical trial of effect of PCC® on the gut microbiome of healthy adults

Current Employment:

  • Bioxyne Limited. Active ingredient in:
    • proTract® for Atopic Dermatitis
    • Progastrim® for gut health, and
    • Progastrim® + Vitamin C for colds
  • Pharmanex (NuSkin). Active ingredient in:
    • ProBioPCC

Contact details:


Dr Peter French, Director of Science, Bioxyne Limited, Sydney

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Why our probiotic products only contain one strain of bacteria – and why that’s good for you

Why our probiotic products only contain one strain of bacteria – and why that’s good for you

The Bioxyne Team

Arkady Lifshits

Our probiotic products contain Bioxyne’s patented probiotic strain, Lactobacillus fermentum VRI-003 (or simply PCC®).

It’s a myth that products containing multiple strains of probiotics are better for you – that’s because we know that different strains do different things and unless those strains have been clinically tested and trialled to see how they react together, no one can really be sure about their impact on health.

Our probiotic, PCC®, has been shown in several clinical studies to boost the immune systems of both adults and infants, and to decrease the incidence and severity of cold symptoms in athletes and infants.

It has also been shown to significantly boost the response to the flu vaccine, and to improve gastrointestinal health.

We know the effective dose is 2 billion live bacteria daily – because we tested that number in several clinical studies. That’s why we have that number of live bacteria in each capsule.

We don’t combine PCC® with any other strains in our products because we don’t know if they might interfere with its potent activity to provide a real health benefit.

So our PCC products contain a single specific strain of a clinically tested probiotic, and the recommended dose is that that has been used in our clinical studies.

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What long-distance runners need to know about PCC®

What long-distance runners need to know about PCC®

The Bioxyne Team

Bruno Nascimento

Endurance training is excellent for heart health but it does take a toll on the immune system.

It has been known since at least 1993 from a range of studies that unusually heavy acute or chronic exercise is associated with an increased risk of upper respiratory tract infections (URTI).

The clinical data supports the concept that heavy exertion increases an athlete's risk of URTI because of negative changes in immune function and elevation of the stress hormones, epinephrine, and cortisol.

The Bioxyne team suspected that PCC would be of benefit to athletes and their compromised immune systems when our own preclinical studies showed that PCC® preferentially bound to the Peyer’s patches in the gut. Peyer’s patches is immune tissue in the gastrointestinal tract that plays a key role in mucosal immunity.

We proposed, therefore, that PCC® may boost the mucosal immune system, providing protection against respiratory tract infections leading to cold and flu symptoms.

In order to examine the ability of PCC® to boost the mucosal immune system in humans, we designed clinical trials on long distance runners and other elite athletes, who are known to be more susceptible to contracting URTIs than the general population.

To carry out the study, we took 20 male elite distance runners in the height of winter. They were training to compete in events ranging from 800 metres to the marathon (42.2 km).

After recruitment, our athletes completed an initial treatment month (28 days)receiving either L. fermentum VRI-003 (PCC®) or placebo. A washout month followed the completion of the first treatment month. Previous studies have shown that it typically takes a probiotic bacteria 3–8 days to pass through the gastrointestinal tract. We then swapped what our participants were taking, so that those receiving PCC® as the first treatment received the placebo as the second treatment and vice versa. The athletes were monitored for an additional fortnight (referred toas ‘‘follow-up’’) after completing the second treatment. During each treatment month subjects were required to take three capsules, twice daily.

Athletes maintained daily diaries recording symptoms, days, severity and medications.

The most important finding of the study was a significant reduction in the number of days of respiratory illness symptoms, and a trend towards a lower severity of illness, during PCC® treatment compared with placebo.

It’s clear from the clinical data that elite endurance athletes can benefit from taking PCC® when undertaking intense training for competitions, because it improves resistance to common illnesses associated with the increase in stress hormones at that time, which will ultimately impede their training and performance.

The study authors noted that “different strains of L. fermentum have different immune-stimulating ability” - PCC® it seems is particularly effective at boosting mucosal immunity in elite athletes.

Learn more about the study here.

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