Your baby’s eczema and probiotic PCC®

Your baby’s eczema and probiotic PCC®

The Bioxyne Team

Colin Maynard

Atopic dermatitis (AD), also known as eczema, is a common inflammatory skin disease affecting 10% of the population.

Eczema has a negative impact on quality of life; visual issues aside, it can be uncomfortably itchy and sore.

The first signs of atopic dermatitis usually appear early in life, from about six months of age, and often precede other allergic diseases such as asthma or allergic rhinitis. The majority of cases (at least 60%) arise within the first year of life.

The symptoms in young children are characterised by dry and scaly patches on the scalp, forehead, and face. These patches are very common on the cheeks.

A clinical study has shown that the probiotic Lactobacillus fermentumVRI-003 (otherwise known as Bioxyne’s PCC®) may alleviate the symptoms of eczema in infants.

Notably, the improvement in symptom severity with PCC® treatment was still evident two months after the treatment stopped.In a follow up scientific study, this was shown to be associated with the ability of PCC® to activate and boost the body’s immune response.

Bioxyne’s Chief Scientific Officer Dr Peter French reviews the findings of these studies in the White Paper: Probiotics in the treatment of atopic dermatitis

Read more about each of the two studies:

Effects of probiotics on atopic dermatitis

Clinical effects of probiotics are associated with increased interferon-g responses in very young children with atopic dermatitis.

 

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Probiotic clinical trial reports Lactobacillus fermentum VRI-003 helps reduce gas and bloating

Probiotic clinical trial reports Lactobacillus fermentum VRI-003 helps reduce gas and bloating

The Bioxyne Team

Australian life sciences company Bioxyne today announces positive results from its Australian clinical trial into the effects of taking a daily probiotic supplement containing the bacteria strain Lactobacillus fermentum VRI-003, with participants who consumed the probiotic reporting a consistent reduction in gas and bloating compared to those on placebo.

Women appeared to benefit more from taking the probiotic than men.

Lactobacillus fermentum VRI-003 has been shown in laboratory studies to inhibit the growth of a range of "unfriendly" microbes, including enterotoxigenic E. coliSalmonella, and Clostridiumv1, which are some of the major organisms responsible for food poisoning and traveller’s diarrhoea. This latest clinical trial indicates it can help reduce gas and bloating when consumed daily, particularly in women, and may therefore be effective in providing symptomatic relief in some cases of gut microbiome dysbiosis disorders.

The double blind, randomised, placebo-controlled clinical trial examined the effect of taking Lactobacillus fermentum VRI-003 (minimum of 2 billion cfus) for six months on the microbiome composition, gut health and quality of life of healthy participants. A total of 47 participants completed the study, with an average age of 35 and an almost even split of men and women.

While the study associated a range of health benefits with taking 2 billion CFU of Lactobacillus fermentum VRI-003, including less antibiotic use, the most notable impact was in relation to the reduction of gas, bloating and general stomach rumbling.

Commenting on the results, Bioxyne’s scientific advisor, cell and molecular biologist Dr Peter French, PhD, said:

“Your gut microbiome is very important for gut health. It can be disrupted by a range of things, including antibiotic use, stress, travel and a poor diet. It’s recognised that gas and bloating can be signs of an unbalanced gut microbiome, which is why we asked the trial participants to report these, amongst other symptoms, during the six-month trial.

“The participants who took the probiotic on a daily basis reported consistently lower incidence of both gas and bloating starting from around six weeks. There was also a consistently lower incidence of stomach rumbling. The women in the study appeared to benefit more from the probiotic treatment – it is recognised that probiotics can affect women and men differently due to sex hormones.

“I would suggest health practitioners working with patients where they suspect symptoms are caused by gut microbiome dysbiosis consider whether supplementation with Lactobacillus fermentum VRI-003 may be appropriate.”

Trial participants were also asked to provide three stool samples for 16S RNA microbiome analysis - one prior to commencing the trial, one at 3 months and the last at 6 months, using a dedicated sample collection kit. In addition, they were asked to complete a daily diary recording gastrointestinal symptoms and bowel movements, a validated quality of life questionnaire (SF36), and a record of any adverse effects. No probiotic-associated adverse effects were reported, and no gross global change was seen in the overall composition of the gut microbiome.

“The lack of significant changes at the phylum or genus level on the microbiome composition in the trial is consistent with previous studies of other probiotic organisms. It is likely that the beneficial effect of Lactobacillus fermentum VRI-003 is due to effects on a small number of key friendly and unfriendly species or strains of gut microbes, as has been seen in laboratory studies of this organism. An effect on specific strains could explain the beneficial effects on some self-reported gut symptoms seen in the trial,” Dr French said.

More about this trial

More about Lactobacillus fermentum VRI-003

The efficacy and safety of Lactobacillus fermentum VRI-003 has been demonstrated by scientific and clinical trials including double-blind, randomized studies with more than 200 people.

In clinical trials, Lactobacillus fermentum VRI-003 has demonstrated positive effects on the gastrointestinal and immune systems, including reduced susceptibility to respiratory tract infections, improvement in eczema (atopic dermatitis) symptoms, and boosting of the immune response to the flu vaccine2.

Lactobacillus fermentum VRI-003 is of human origin, exhibits superior survival to other probiotics in the acidic (pH 2-4) environment found in the stomach and large intestine, colonises the human intestinal tract and stimulates the areas of immune tissue in the small intestine2.

Bioxyne has trademarked Lactobacillus fermentum VRI-003 ‘PCC’. Read Why PCC.

Shop Bioxyne’s probiotic products 

1data on file
2data on file

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How probiotics are named

How probiotics are named

The Bioxyne Team1 comment

Alona Kraft

There are over 120 different species of Lactobacillus. The most famous ones are Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri and Lactobacillus fermentum. (We italicise their names as a scientific convention, for some reason).

In each species there are thousands of individual members referred to as “strains”. A bacterial strain has its strain name after the species name. So, Bioxyne’s probiotic is a strain of the Lactobacillus fermentum species. The strain is VRI-003, so its full name is Lactobacillus fermentum VRI-003.

To understand the relationship between a species and its strains, think about us humans. All seven billion of us on Earth are members of the Homo sapiens species. But we are all individually different, and are good at different things. The same is true with Lactobacillus acidophilus, and all the other Lactobacillus species. Some are really good for our health, and some aren’t. Just because you are a human doesn’t mean you can paint like Vincent van Gogh, or sing like Adele, or dance like Fred Astaire, right? Individual members of the human species have different talents and abilities. So it is with probiotics.

You can’t tell what the talents of a probiotic bacterial strain are by looking at it (under a microscope). Scientists have to test them in the lab and in people, before they can know whether they are going to be useful for health, or not. Many are useless. However, some are very useful.

Can it do the job? Checking the resume of a probiotic

In applying for a job, people prepare a resume. You wouldn’t employ someone who just walked in off the street without interviewing them or looking at their resume to see if they had the right qualifications or experience first, would you? Similarly, you shouldn’t buy a probiotic product without checking out the resume of the bacteria first.

Here are the things you should look for on a probiotic’s resume:

  • Name: What is the species and strain name? If it doesn’t have a strain name, you don’t know which of the thousands of possible members of that species are in the bottle
  • Where it comes from: For human health you want to have a probiotic that comes from a human (rather than from a cow or a plant) 
  • How it performs under stress: Look for evidence that it can get through the stomach acid and bile,and remain alive and kicking
  • It doesn’t have a criminal record: Check that it doesn’t cause disease when consumed
  • Has a track record and list of achievements:
    • Sticks to the walls of the intestinal tract
    • Is able to get rid of“bad” bacteria in the GI tract
    • Is able to demonstrate its health benefit credentials in clinical trials

Bioxyne’s patented probiotic Lactobacillus fermentum VRI-003 (or PCC® for short – PCC® stands for patented clinical culture) meets all these criteria – see the resume below.

That’s why we have selected PCC® as the key ingredient in our range of PCC® products for gastrointestinal and immune health.

This was part two of a four-part series about what probiotics are and why they’re good for you. Next up is ‘How probiotics work’, followed by ‘How to take your probiotics’.

Read part one: What are probiotics?

Resume´ 

Name: Lactobacillus fermentum VRI-003

Nickname: PCC®

Origin: A human with robust gastrointestinal health

Career Objective: To boost gut and immune health of adults and infants through daily dosing of clinically trialled doses of PCC®.

Qualifications:

University of New South Wales:

  • Certificate of High Survival in Stomach Acid and Bile
  • Certificate of Inhibition of Gastrointestinal Pathogens
  • Certificate of Binding to the Intestinal tract

Previous Experience in Humans:

2005: Clinical trial of PCC® showing improvement in symptoms of moderate to severe atopic dermatitis in infants

2008: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

2009: Clinical trial of PCC® showing boost in the immune response to the flu vaccine

2011: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

All of these trials confirmed that PCC® is safe for children and adults

Current Experience in Humans:

2016- present: Clinical trial of effect of PCC® on the gut microbiome of healthy adults

Current Employment:

  • Bioxyne Limited. Active ingredient in:
    • proTract® for Atopic Dermatitis
    • Progastrim® for gut health, and
    • Progastrim® + Vitamin C for colds
  • Pharmanex (NuSkin). Active ingredient in:
    • ProBioPCC

Contact details:

www.bioxyne.com

Referee

Dr Peter French, Director of Science, Bioxyne Limited, Sydney

 

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Odette Blacklock on finding her way to health and fitness

Odette Blacklock on finding her way to health and fitness

The Bioxyne Team

If Bioxyne affiliated practitioner Odette Blacklock looks familiar, it’s likely because 2017 saw the health and fitness specialist gracing our TVs as a Survivor Australia castaway. An almost all-encompassing expert when it comes to movement, Odette’s list of credentials covers podiatry, running, personal training and pilates. Odette also recently celebrated being appointed head coach and program director of Virgin Active’s new outdoor running program.

Odette took time out for her insanely busy schedule to talk to us about her own wellbeing rituals and how she factors gut health into her overall health regimes.

Learn more about the benefits of becoming a Bioxyne affiliated practitioner.

 

How long have you been a health practitioner for?

I have been in the health and fitness industry as a personal trainer and pilates instructor for over 10 years. Recently graduating from a Masters in Podiatrist Medicine, I have been practicing in my clinic for almost two years. Because of my expertise in gait mechanics, I am the head coach and program director of Virgin Actives new Outdoor running program.

Where does your interest in health and wellbeing originate?

It originates from my own personal experience with depression. After having my son I fell into unhealthy habits. The only thing that felt most accessible to me was running. This gave me the momentum to fix other areas of my life including diet, I then endeavoured to learn more about health and fitness by doing my personal training certificate, which lead me to doing my bachelors of health science and later my Masters in Podiatrist Medicine. I am always constantly learning and growing in this area, and my passion lies in being able to educate and teach people on how to improve their health and love their bodies.

What have been your career highlights and what are you working on at the moment?

After graduating with my Masters in 2016, I was lucky enough to be 1 of 2 Australians chosen to run in Death Valley for Under Armours Run Camp.  This run made me redefine my own mental toughness, whilst showing me how far I have come on my journey. The following year I applied for Australian Survivor season 2 and stepped foot on the island a few months later, to learn yet again how mentally tough you have to be to survive. Being on the island allowed me to put life in perspective and find clarity for the future. I realised how much running had changed my life, so I founded Urban Run Club, and it quickly took off. This run group and my unique methods of training runners captured the attention of Virgin Active. A position has been created in the company and I am now head coach of my own program written and directed by me. I absolutely love the fact that I can bring running to a bigger audience.

Is there one piece of wellbeing advice you consistently find you give to your clients?

The hardest part is turning up- just make the effort to turn up consistently. Whether it’s two minutes of exercise or two hours, every bit gets added to the bank.

Do you have any wellbeing rituals you practice at home?

Cold showers and meditation. The mind is important to look after and these two practices allow me to be in the present moment and clam my thoughts. I also love a glass of wine and a Ted Talk ;)

How do you take care of your own gut health?

I obviously use a probiotic daily, and since using Bioxyne probiotics for myself and my son, we have not been sick once. I also make sure I feed my gut an array of vegetables and good fibre for the probiotics to eat and serve their purpose in the lower GI tract.

What do you see as the role of probiotics to health and wellbeing?

Our gut microbiome has over 100 trillion microbial cells compared to our 10 trillion human cells. So when these cells communicate they have a tremendous impact on our health.  Numerous scientific studies have proven the beneficial effects of taking a high quality probiotic supplement, linking probiotics to weight management, higher energy levels, mental clarity and a stronger immune system.

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The Importance of Knowing That Your Probiotic Is What It Says It Is

The Importance of Knowing That Your Probiotic Is What It Says It Is

Dr Peter French

In January 2018, Professor Claudio de Simone published a paper in the journal “Clinical Gastroenterology and Hepatology” in which he sent a warning about many of the commercial probiotics on the market. In the paper, entitled “The unregulated probiotic market”, Professor de Simone, who is an internationally recognised leader in the field of probiotics and the human gut microflora, stated:

“Many properties of probiotics are strain-specific, and safety and efficacy findings associated to specific formulations should not be generalised to other probiotic products.” This is crucial, because we at Bioxyne Limited know that not all probiotics provide a health benefit. We have undertaken several clinical studies to show that the specific strain in Progastrim®, PCC®, is highly effective at boosting gut and immune health.

Professor de Simone went on to say: “Manufacturing processes, conditions and ingredients are important determinants of product characteristics and changes to manufacturing are likely to give rise to a product not identical to the "original" in efficacy and safety if proper measures and controls are not taken.”

Bioxyne’s probiotic products are manufactured to the highest standards by world-leading probiotic manufacturer Chr Hansn, based in Denmark. This ensures that each batch of PCC® is the same consistent quality.

Professor de Simone concluded: “These regulatory deficits may have serious consequences for patients where probiotics are used as part of clinical guideline-recommended management of serious conditions such as inflammatory bowel diseases, and may make doctors liable for prescribing a formulation not previously tested for safety and efficacy.”

Bioxyne’s dedication to clinical studies, manufacturing stringency and quality control ensures that consumers, patients and doctors alike can be confident that Progastrim®, does what it says it does in boosting gut and immune health.

Reference:
de Simone C. Clin Gastroenterol Hepatol. 2018 Jan 25. pii: S1542-3565 (18) 30084-3. doi: 10.1016/j.cgh.2018.01.018.

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How probiotics can influence brain function

How probiotics can influence brain function

Dr Peter French

Scientists from the California Institute of Technology (Caltech) and the University of California Los Angeles (UCLA) in November 20161 have demonstrated that the health of the gastrointestinal tract plays a key role in regulating healthy brain function. In a paper in the very prestigious international peer reviewed scientific journal Cell, the researchers reviewed 194 published papers that provide evidence for gut bacteria being “integral contributors to development and function of the nervous system and to the balance between mental health and disease”.

 They presented evidence that showed the gut microbiome (the bacteria that reside in the gastrointestinal tract of humans) and/or probiotics could play a key role in a range of neuropsychiatric conditions, including depression and anxiety, autism spectrum disorder, schizophrenia, Parkinson’s disease (PD) and Alzheimer’s disease (AD) . This was further supported by researchers from the Chinese Academy of Sciences who provided evidence for the role of the microbiome, and, by implication, probiotics, in dementia2.

 

The role of the gut microbiome and probiotics in human health.

The authors acknowledge that the gut microbiome plays a significant role in the wellbeing of its host. Consumption of probiotics supplements the gut microbial population with a specific microbe, either transiently or permanently, and can change the microbiome profile and function, as well as interact with the host to produce a range of beneficial health effects. The effect of probiotics on immune health was clearly stated by the researchers: “Research in animal models and humans has inextricably linked gut bacteria to the development and function of the immune system. The presence of entire immune cell types requires the microbiome, and specific microbes have been discovered that either promote or ameliorate immunologic disorders such as type 1 diabetes, asthma, and inflammatory bowel disease.”

"Research in animal models and humans has inextricably linked gut bacteria to the development and function of the immune system" 

In both papers the authors predominantly focused on evidence for the role of the gut microbiome in nervous system disorders.

 

Evidence for the ability of probiotics and the gut microbiome to influence mood:

 

  • A study in healthy volunteers who consumed a fermented milk product containing probiotic bacteria showed alterations in brain activity during an attention task, in brain regions that control processing of sensation and emotion, in comparison to a control group who consumed a milk drink without probiotic bacteria.

  • Another study in humans associated the gut microbiome in IBD with stress disorders.
  • Gastrointestinal symptoms are associated with depression, with around 20% of patients reporting such symptoms.
  • The composition of the gut microbiome in major depressive disorder (MDD) patients is significantly different from that of healthy controls3. When fecal samples from MDD

 "Mouse and human studies provide tantalizing suggestions that the microbiome may play an active role in driving depressive-like behaviors suggesting potential new avenues for therapeutic development"

  1. Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. The Central Nervous System and the gut microbiome. Cell 2016; 167: 915-32.
  2. Alkasir R, Li J, Li X, Jin M, Zhu B. Human gut microbiota: the links with dementia development. Protein Cell 2016; DOI 10.1007/s13238-016-0338-6
  3. Significantly more Actinobacteria and less Bacteroidetes in MDD-associated microbial populations

 

 

patients and controls were transplanted to mice, the recipients of MDD samples exhibited much more depressive-like behaviour compared to controls

 

Evidence for the role of probiotics and the gut microbiome in autism spectrum disorder (ASD):

  • The gut microbiome of ASD patients has an increased abundance and diversity of “unhealthy” bacteria4.
  • The gut microbiome of ASD patients often lacks probiotic bacteria.

  • Gastrointestinal symptoms such as diarrhea are significantly more prevalent in children with ASD.

 

Evidence for probiotics and the gut microbiome in dementia

Dementia is a syndrome that affects memory and other cognitive functions to the extent that it interferes with daily function. There are many conditions that can cause dementia, including neurodegenerative disorders [e.g. Alzheimer’s disease (AD) and Parkinson’s disease (PD)], cerebrovascular disease, brain injury, and certain infections. There are several studies cited by the authors that imply a role of the gut microbiome in AD and PD:

 

  • Individuals afflicted with PD display significantly different fecal and mucosal microbial populations:
    • There are increased numbers of tissue-associated E. coli in the gut of PD patients compared to healthy controls,
    • Furthermore, short chain fatty acid (SCFA) concentrations in feces from PD patients are decreased as compared to controls. SCFA are produced by bacterial fermentation in the gut, and are needed for normal nervous system development.

     

    • Recent evidence suggests that molecules from bacteria present in the microbiota can trigger autoimmune responses that promote neurodegeneration during AD and PD.
    • There are marked differences in the composition of the gut microbiome between AD mice and healthy mice and strongly indicated that a distinct microbial population in AD mice may play a role in the development of the disease.

     

    Conclusion

    From their extensive review of the literature, the American group conclude that there is a growing understanding of how different gastrointestinal tract microbial populations, beneficial or pathogenic, regulate the nervous system in health and disease. They contend that, “this holds promise in the diagnosis, treatment, and prevention of some specific neuropathologies. Determining how a microbiome, changing with Westernisation and other environmental factors, impacts a human population with growing rates of neurodevelopmental disorders and increasing life expectancy represents an urgent challenge to biomedical research and to society.”

    The Chinese group reports a similar result. They propose that modulation of the gut microbiota (by probiotics or other dietary intervention) is a growing area of interest for the pharmaceutical and functional food industries, with the goal of decreasing the incidence of diseases associated with Westernisation and longevity, including Alzheimer’s disease.

    4 These were reported to include Clostridia species, non-spore-forming anaerobes, microaerophilic bacteria and Sutterella. 

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    Could Bad Gut Health Be Causing These Common Health Issues?

    Could Bad Gut Health Be Causing These Common Health Issues?

    The Bioxyne Team

    The connection between digestive issues and the gut microbiome is now well understood by consumers, but what many people don’t know is that gut health is connected to a host of other common ailments.

    Fashion, beauty and lifestyle blog See.Need.Want recently interviewed Bioxyne’s Chief Scientist Dr Peter French, who has studied the connection between the microbiome and immune health since 2002.

    In this detailed interview, Peter explains the importance of maintaining gut health, how gut bacteria affects the immune system and mental health, and what we know about how PCC (Lactobacillus fermentumVRI-003) affects all these things.

    “PCC® has been shown to be effective at inhibiting a range of pathogenic bacteria in the laboratory, and to boost immune and gut health in clinical studies,” Peter told See.Need.Want editor Rosie McKay. “Given the clear connection between the gut and the brain, PCC® is likely to have a positive effect on the function of both.”

    Read the interview

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    Hay fever and PCC®

    Hay fever and PCC®

    The Bioxyne Team


    Olia Gozha

    With Spring on the way, while most of us look forward to warmer weather and longer days, those of us who suffer from severe symptoms of hay fever are less excited. Many dread the onset of itchy eyes, runny noses and constant sneezing. Some turn to over the counter drugs to dry up their symptoms. But there may be a better way.

    With the increased knowledge that out gut microbiome is critical for a range of health conditions, including our immune system, researchers have focused on the use of probiotics – good bacteria – to assist with our gut and immune health. And now there is evidence that probiotics could alleviate the symptoms of hay fever. There are at least 18 studies that show that some probiotics can produce a significant improvement in symptoms and quality of life in hay fever sufferers. How they do this appears to be by boosting what is called the Th1 immune response.

    A clinical study on babies with moderate to severe eczema, which, like hay fever is a response to an environmental allergen, showed that Bioxyne’s probiotic, called PCC® (A Lactobacillus strain) boosted the Th1 immune response and significantly improved the symptoms of eczema in comparison to a placebo control.

    PCC® therefore is likely to have a similar effect on hay fever symptoms. And it has been shown to boost gut health as well! You don’t get that benefit with the OTC hay fever drugs!

     

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    How to take your probiotics

    How to take your probiotics

    The Bioxyne Team

    Dominik Martin

    It’s simple. The PCC® in Bioxyne’s products is freeze dried – which means that all you need to do to bring it back to life is to swallow it with plenty of water. 

    For proTract for infants with atopic dermatitis, just open a capsule and sprinkle it onto your infant’s drink (if it’s a warm drink, add the probiotic after you have warmed it up).

    For adults, you can take one Progastrim® or Progastrim®+Vitamin C capsule with a glass of water every day.

    If you are taking antibiotics, wait at least two hours after your antibiotic dose before consuming PCC® in either Progastrim® or proTract products.

    This was part four of a four-part series about what probiotics are and why they’re good for you.

    Part one: What are probiotics?

    Part two: How probiotics are named

    Part three: How probiotics work and why they’re good for you

     

     

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    How probiotics work and why they’re good for us

    How probiotics work and why they’re good for us

    The Bioxyne Team

    Christopher Campbell

    Scientists now understand that the health of our gastrointestinal (GI) tract is vital to our health generally. Scientific studies have demonstrated that probiotics can directly influence our health primarily through their effects on the GI tract. These effects include:

    • helping to maintain a healthy balance of intestinal microbes,
    • preventing pathogenic microbes from inhabiting the intestinal tract,
    • boosting the general immune response through stimulating important immune areas located in the intestinal tract,
    • maintaining the health of the intestinal wall to stop bacteria getting through it and causing disease,
    • inhibiting cancer-associated enzymatic activity, and
    • nurturing the intestine’s ability to absorb healthy nutrients.

    The health benefits of probiotics

    Foods fermented by probiotic bacteria (think kimchee, yoghurt, sauerkraut) have for centuries been revered as health-giving, but it’s only in the last few decades that scientists have begun to compile solid scientific data that supports the association between probiotics and good health.

    Have a look at the graph below to see the growth in scientific research on probiotics in the past 20 years.

    (Source: NCBI PubMed)

    While the association between gastrointestinal health and probiotics has been widely accepted, more recently we’re seeing a clear association between probiotics and immune health.

    It’s important to note that unless a probiotic strain has been tested, we don’t really know if it has any health benefits.

    Bioxyne’s probiotic PCC® has been scientifically and clinically tested in Australia. Through double-blind, placebo-controlled studies, PCC® has demonstrated clinical efficacy in:

    • reducing the incidence and severity of respiratory infections (colds) in infants and adults
    • reducing the symptoms of moderate to severe atopic dermatitis (eczema) in infants
    • boosting the effectiveness of the FluVax (flu vaccinations)
    • improving bowel function in adults.

    This was part three of a four-part series about what probiotics are and why they’re good for you. Next up is ‘How to take your probiotics’.

    Part one: What are probiotics

    Part two: How probiotics are named

    Resume´

    Name: Lactobacillus fermentum VRI-003

    Nickname: PCC®

    Origin: A human with robust gastrointestinal health

    Career Objective: To boost gut and immune health of adults and infants through daily dosing of clinically trialled doses of PCC®.

    Qualifications:

    University of New South Wales:

    • Certificate of High Survival in Stomach Acid and Bile
    • Certificate of Inhibition of Gastrointestinal Pathogens
    • Certificate of Binding to the Intestinal tract

    Previous Experience in Humans:

    2005: Clinical trial of PCC® showing improvement in symptoms of moderate to severe atopic dermatitis in infants

    2008: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

    2009: Clinical trial of PCC® showing boost in the immune response to the flu vaccine

    2011: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes

    All of these trials confirmed that PCC® is safe for children and adults

    Current Experience in Humans:

    2016- present: Clinical trial of effect of PCC® on the gut microbiome of healthy adults

    Current Employment:

    • Bioxyne Limited. Active ingredient in:
      • proTract® for Atopic Dermatitis
      • Progastrim® for gut health, and
      • Progastrim® + Vitamin C for colds
    • Pharmanex (NuSkin). Active ingredient in:
      • ProBioPCC

    Contact details:

    www.bioxyne.com

    Referee

    Dr Peter French, Director of Science, Bioxyne Limited, Sydney

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