Atopic dermatitis (AD), also known as eczema, is a common inflammatory skin disease affecting 10% of the population.
Eczema has a negative impact on quality of life; visual issues aside, it can be uncomfortably itchy and sore.
The first signs of atopic dermatitis usually appear early in life, from about six months of age, and often precede other allergic diseases such as asthma or allergic rhinitis. The majority of cases (at least 60%) arise within the first year of life.
The symptoms in young children are characterised by dry and scaly patches on the scalp, forehead, and face. These patches are very common on the cheeks.
A clinical study has shown that the probiotic Lactobacillus fermentumVRI-003 (otherwise known as Bioxyne’s PCC®) may alleviate the symptoms of eczema in infants.
Notably, the improvement in symptom severity with PCC® treatment was still evident two months after the treatment stopped.In a follow up scientific study, this was shown to be associated with the ability of PCC® to activate and boost the body’s immune response.
Bioxyne’s Chief Scientific Officer Dr Peter French reviews the findings of these studies in the White Paper: Probiotics in the treatment of atopic dermatitis
Read more about each of the two studies:
Effects of probiotics on atopic dermatitis
Clinical effects of probiotics are associated with increased interferon-g responses in very young children with atopic dermatitis.
It’s simple. The PCC® in Bioxyne’s products is freeze dried – which means that all you need to do to bring it back to life is to swallow it with plenty of water.
For proTract for infants with atopic dermatitis, just open a capsule and sprinkle it onto your infant’s drink (if it’s a warm drink, add the probiotic after you have warmed it up).
For adults, you can take one Progastrim® or Progastrim®+Vitamin C capsule with a glass of water every day.
If you are taking antibiotics, wait at least two hours after your antibiotic dose before consuming PCC® in either Progastrim® or proTract products.
This was part four of a four-part series about what probiotics are and why they’re good for you.
Part one: What are probiotics?
Part two: How probiotics are named
Part three: How probiotics work and why they’re good for you
Scientists now understand that the health of our gastrointestinal (GI) tract is vital to our health generally. Scientific studies have demonstrated that probiotics can directly influence our health primarily through their effects on the GI tract. These effects include:
- helping to maintain a healthy balance of intestinal microbes,
- preventing pathogenic microbes from inhabiting the intestinal tract,
- boosting the general immune response through stimulating important immune areas located in the intestinal tract,
- maintaining the health of the intestinal wall to stop bacteria getting through it and causing disease,
- inhibiting cancer-associated enzymatic activity, and
- nurturing the intestine’s ability to absorb healthy nutrients.
The health benefits of probiotics
Foods fermented by probiotic bacteria (think kimchee, yoghurt, sauerkraut) have for centuries been revered as health-giving, but it’s only in the last few decades that scientists have begun to compile solid scientific data that supports the association between probiotics and good health.
Have a look at the graph below to see the growth in scientific research on probiotics in the past 20 years.
(Source: NCBI PubMed)
While the association between gastrointestinal health and probiotics has been widely accepted, more recently we’re seeing a clear association between probiotics and immune health.
It’s important to note that unless a probiotic strain has been tested, we don’t really know if it has any health benefits.
Bioxyne’s probiotic PCC® has been scientifically and clinically tested in Australia. Through double-blind, placebo-controlled studies, PCC® has demonstrated clinical efficacy in:
- reducing the incidence and severity of respiratory infections (colds) in infants and adults
- reducing the symptoms of moderate to severe atopic dermatitis (eczema) in infants
- boosting the effectiveness of the FluVax (flu vaccinations)
- improving bowel function in adults.
This was part three of a four-part series about what probiotics are and why they’re good for you. Next up is ‘How to take your probiotics’.
Part one: What are probiotics
Part two: How probiotics are named
Name: Lactobacillus fermentum VRI-003
Origin: A human with robust gastrointestinal health
Career Objective: To boost gut and immune health of adults and infants through daily dosing of clinically trialled doses of PCC®.
University of New South Wales:
- Certificate of High Survival in Stomach Acid and Bile
- Certificate of Inhibition of Gastrointestinal Pathogens
- Certificate of Binding to the Intestinal tract
Previous Experience in Humans:
2005: Clinical trial of PCC® showing improvement in symptoms of moderate to severe atopic dermatitis in infants
2008: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes
2009: Clinical trial of PCC® showing boost in the immune response to the flu vaccine
2011: Clinical trial of PCC® showing reduction in symptoms of respiratory tract infections in elite male athletes
All of these trials confirmed that PCC® is safe for children and adults
Current Experience in Humans:
2016- present: Clinical trial of effect of PCC® on the gut microbiome of healthy adults
- Bioxyne Limited. Active ingredient in:
- proTract® for Atopic Dermatitis
- Progastrim® for gut health, and
- Progastrim® + Vitamin C for colds
- Pharmanex (NuSkin). Active ingredient in:
Dr Peter French, Director of Science, Bioxyne Limited, Sydney
Our probiotic products contain Bioxyne’s patented probiotic strain, Lactobacillus fermentum VRI-003 (or simply PCC®).
It’s a myth that products containing multiple strains of probiotics are better for you – that’s because we know that different strains do different things and unless those strains have been clinically tested and trialled to see how they react together, no one can really be sure about their impact on health.
Our probiotic, PCC®, has been shown in several clinical studies to boost the immune systems of both adults and infants, and to decrease the incidence and severity of cold symptoms in athletes and infants.
It has also been shown to significantly boost the response to the flu vaccine, and to improve gastrointestinal health.
We know the effective dose is 2 billion live bacteria daily – because we tested that number in several clinical studies. That’s why we have that number of live bacteria in each capsule.
We don’t combine PCC® with any other strains in our products because we don’t know if they might interfere with its potent activity to provide a real health benefit.
So our PCC products contain a single specific strain of a clinically tested probiotic, and the recommended dose is that that has been used in our clinical studies.